Comparative Gerontology--From Mussels to Man

Molecular gerontology: from homeodynamics to hormesis.

The science and study of the biological basis of aging, biogerontology, is now a well-established field with solid scientific base. A paradigm-shift in gerontology has occurred by realising the fact that biological aging occurs in spite of the presence of complex homeodynamic pathways of maintenance, repair and defence, and there is no "enemy within". This viewpoint separates the modulation of ...

From decriminalization to infringementlism (comparative study)

The entry of the government into the circle of permissible behaviors and the criminalization of some of them have certain bases. The mere fact that the norm is fundamental is not a reason for criminal intervention. Because the norms are not equally important, the legislature cannot treat them all the same, because the subject matter of all prohibited behaviors is different, and the proof of thi...

Bioactive agents from marine mussels

Experimental Gerontology

Most definitions of frailty utilize US populations in their development. The concept of frailty has not been well studied in Japan, which has the largest percentage of older patients (per capita) in the world. We created a 5-year prospective cohort study of community-dwelling older Japanese adults. Participants were not frail at baseline, based on our definition adapted from the Canadian Study ...

Extrapolation from mouse to man.

Despite the above caveat, the impressive new technology described by Gupta et al1 in this issue of Circulation: Cardiovascular Imaging should help to resolve a number of issues relative to the hypothesis that the failing heart is energy starved and that depressed high-energy phosphate flux through the creatine kinase (CK) system is a causative factor.2,3 It will allow longitudinal measurements ...